About our group
Research projects within the group predominantly focus on the development of inhibitors targeting enzymes involved in nucleoside and nucleotide metabolism. The rational design of novel modified nucleosides and nucleotides, particularly acyclic nucleoside phosphonates and their prodrugs, is based on extensive structure–activity relationship studies previously carried out in our group, and on computational simulations.
Efficient synthetic methodologies employing diverse approaches from modern organic chemistry are developed for the preparation of target compounds. These structures are designed regarding their anticipated antiviral, cytostatic, antiparasitic, and antibacterial activities arising from inhibition of key enzymes. The mechanisms of action of the prepared antimetabolites and their potential biomedical applications are investigated in collaboration with numerous scientific groups worldwide.
Publications
All publications
